Protein Modification Reagents
![Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-maleimide] ammonium | 474922-22-0 | >95.0% | 3,400 Da | (C2H4O)nC51H92N3O13P.H3N | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000281718.png-250.jpg)
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[poly(ethylene glycol)-maleimide] ammonium | 474922-22-0 | >95.0% | 3,400 Da | (C2H4O)nC51H92N3O13P.H3N | 250 MG
DSPE-PEG-Maleimide (MW 3400) ammonium is a PEGylated phospholipid bearing a terminal maleimide group and supplied as the ammonium salt. It is used to introduce thiol-reactive functionality into liposomes, micelles, and other nanostructured lipid carriers for conjugation of peptides, proteins, and thiolated ligands in drug delivery and nanomedicine research.
- Provides a terminal maleimide for selective conjugation to thiol groups.
- PEG spacer (MW ~3,400) improves steric stabilization and circulation time.
- DSPE lipid anchor enables stable incorporation into lipid bilayers and micelles.
- Ammonium salt form aids solubility and handling in formulation workflows.
- Typical purity ≥95% suitable for research applications; verify COA for critical uses.
eMolecules 1334177-86-4 | Mal-amido-PEG8-acid | Broadpharm | MFCD13184956 | 592.639 | C26H44N2O13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 100mg | 249969292
Mal-amido-PEG8-acid | Broadpharm | 1334177-86-4 | MFCD13184956 | 592.639 | C26H44N2O13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 100mg | 249969292
eMolecules 882847-34-9 | Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 250mg | 525195262
Fmoc-NH-PEG6-CH2CH2COOH | Ambeed | 882847-34-9 | MFCD06656474 | 575.655 | C30H41NO10 | 95.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 250mg | 525195262
Medchemexpress LLC Dspe-peg-sh | 99.4% | 2000 (average) | (C2H4O)nC45H87N2O10PS | 25 MG
DSPE-PEG-SH is a thiolated pegylated phospholipid (average MW 2000) that provides a terminal -SH for covalent surface modification of lipid assemblies. Its amphipathic DSPE-PEG structure enables incorporation into liposomes and lipid nanoparticles for ligand attachment, stabilization, and targeted delivery via formation of stable thioether bonds with maleimide-functionalized molecules.
- Provides a terminal thiol for covalent conjugation.
- Incorporates into lipid bilayers for surface functionalization.
- Enables stable thioether linkage with maleimide reagents.
- Suitable for liposome and lipid nanoparticle formulations.
- Facilitates targeted delivery via ligand attachment.
- Reported high purity supports reproducible formulation.
- Soluble in water and DMSO with warming and sonication.
eMolecules 3,4-Dibromo-Mal-PEG4-amide-DBCO | Broadpharm |761.464 | C33H35Br2N3O8 | 98.000 | BrC1=C(Br)C(=O)N(CCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)C1=O | 10mg | 784454982
3,4-Dibromo-Mal-PEG4-amide-DBCO | Broadpharm |761.464 | C33H35Br2N3O8 | 98.000 | BrC1=C(Br)C(=O)N(CCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)C1=O | 10mg | 784454982
ABclonal Technology RIN2 Rabbit pAb
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants.
eMolecules 2112734-70-8 | N-(Hydroxy-PEG3)-N-bis(PEG4-t-butyl ester) | Broadpharm | MFCD30730366 | 802.009 | C38H75NO16 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCN(CCOCCOCCOCCO)CCOCCOCCOCCOCCC(=O)OC(C)(C)C | 500mg | 347153824
N-(Hydroxy-PEG3)-N-bis(PEG4-t-butyl ester) | Broadpharm | 2112734-70-8 | MFCD30730366 | 802.009 | C38H75NO16 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCN(CCOCCOCCOCCO)CCOCCOCCOCCOCCC(=O)OC(C)(C)C | 500mg | 347153824
eMolecules 185022-12-2 | Aminooxy-PEG2-alcohol | Broadpharm | MFCD30182047 | 121.136 | C4H11NO3 | 98.000 | NOCCOCCO | 500mg | 309208988
Aminooxy-PEG2-alcohol | Broadpharm | 185022-12-2 | MFCD30182047 | 121.136 | C4H11NO3 | 98.000 | NOCCOCCO | 500mg | 309208988
Medchemexpress LLC Biotin-PEG4-acid | 721431-18-1 | 97.0% | 50 MG
Biotin-PEG4-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound leverages the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins. It has a molecular weight of 491.60 and a chemical formula of C21H37N3O8S, appearing as a white to off-white solid.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
- Molecular weight of 491.60
- Chemical formula C21H37N3O8S
- Appears as a white to off-white solid
- Recommended for research use only
Medchemexpress LLC Chloroacetamido-PEG4-C2-Boc | 1365655-90-8 | ≥97.0% | 100 MG
Chloroacetamido-PEG4-C2-Boc is a PROTAC linker, a molecule designed to induce the degradation of target proteins. It belongs to the PEG and Alkyl/ether class, and its tetraethylene glycol component can be utilized in the synthesis of various PROTAC molecules.
- Acts as a PEG/Alkyl/ether-based PROTAC linker
- Contains two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase, the other for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC T-Boc-N-amido-PEG5-acetic acid | 890152-41-7 | 98.0% | 395.45 g/mol | C17H33NO9 | 250 MG
t-Boc-N-amido-PEG5-acetic acid is a Boc-protected PEG5 linker containing a terminal carboxylic acid and a Boc-protected amine. It is intended for research use and is commonly used as a spacer in PROTAC synthesis and bioconjugation workflows where a hydrophilic, flexible linker is required. The product is offered in multiple package sizes and is characterized by analytical data suitable for synthetic applications.
- Boc-protected amine enabling selective deprotection.
- Terminal carboxylic acid for straightforward amide coupling.
- PEG5 spacer provides a hydrophilic, flexible linkage.
- Reported analytical purity suitable for synthetic use.
- Available in multiple package sizes for research needs.
- Provided for research use only, not for personal use.
