Protein Modification Reagents
Medchemexpress LLC N-Boc-PEG5-bromide | 1392499-32-9 | MFCD31536756 | 98.0% | 400.31 g/mol | C15H30BrNO6 | 500 MG
N-Boc-PEG5-bromide is a Boc-protected polyethylene glycol (PEG5) alkyl bromide linker used as a building block in medicinal chemistry for PROTAC and ADC linker synthesis. It provides an orthogonally protected amine and a terminal bromide for downstream coupling and substitution reactions. Supplied with high reported purity, it is intended for research use under appropriate laboratory conditions.
- Boc-protected amine for orthogonal deprotection.
- Five-unit PEG spacer provides flexibility and solubility.
- Terminal bromide enables nucleophilic substitution (SN2) chemistry.
- Reported purity approximately 98.0%.
- Suitable for assembly of PROTAC and ADC linkers.
- Recommended cold storage to preserve stability.
Medchemexpress LLC Cy5-PEG3-endo-BCN | 1881221-50-6 | 98.4% | 869.57 | C51H69ClN4O6 | 10 MG
Cy5-PEG3-endo-BCN is a Cyanine 5 dye derivative containing a three-unit polyethylene glycol spacer and an endo-BCN reactive group. Supplied as a purple to purplish-red solid for research use, it is designed for bioorthogonal labeling of azide-containing biomolecules via catalyst-free strain-promoted azide-alkyne cycloaddition.
- Dye derivative with PEG3 spacer to improve solubility in aqueous media.
- Endo-BCN functional group enables catalyst-free click chemistry labeling.
- High purity suitable for sensitive fluorescence labeling applications.
- Purple solid appearance for easy visual confirmation.
- Recommended storage under inert atmosphere at low temperatures.
- Available in small milligram pack sizes for laboratory research.
Medchemexpress LLC Bromoacetamido-PEG5-DOTA | 2353410-19-0 | 98.0% | C30H55BrN6O13 | 50 MG
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These compounds employ two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein. PROTACs leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product appears as a white to off-white oil.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Appears as a white to off-white oil
- For research use only
eMolecules Propargyl-PEG24-amine | 956348-61-1 | MFCD30723251 | 1g
Broadpharm | Propargyl-PEG24-amine | 1g | 340376890 | BP-23544 | 98.000 | 956348-61-1 | MFCD30723251 | 1112.352 | C51H101NO24
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eMolecules N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 2055042-60-7 | MFCD30182039 | 500mg
Broadpharm | N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 500mg | 309208953 | BP-23264 | 97.000 | 2055042-60-7 | MFCD30182039 | 556.694 | C25H52N2O11
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Medchemexpress LLC Mal-amido-PEG5-C2-NHS ester | 1315355-92-0 | ≥98.0% | 557.55 g·mol⁻1 | C24H35N3O12 | 100 MG
Mal-amido-PEG5-C2-NHS ester is a noncleavable linker reagent combining a maleimide and an N-hydroxysuccinimide (NHS) ester for thiol- and amine-directed bioconjugation. It is intended for labeling primary amines and for constructing stable linkages in antibody-drug conjugates, protein, and oligonucleotide conjugations.
- Contains maleimide for thiol-selective conjugation
- Contains NHS ester reactive toward primary amines
- High purity (≥98.0%) suitable for research use
- Molecular weight ~557.55 and formula C24H35N3O12
- Available in a 100 mg package for lab-scale synthesis and labeling workflows
Medchemexpress LLC Bromo-PEG4-azide | 1951439-37-4 | 98.1% | C10H20BrN3O4 | 250 MG
Bromo-PEG4-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups
Medchemexpress LLC Biotin-PEG4-amide-Alkyne | 1006592-45-5 | 95.0% | C24H40N4O7S | 25 MG
Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. PROTACs leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group for CuAAc reactions
- Degrades target proteins via the ubiquitin-proteasome system
Medchemexpress LLC DOTA-PEG5-azide | 3104986-47-9 | 98.0% | C28H52N8O12 | 25 MG
DOTA-PEG5-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Intended for research use only